Hydrochloric Acid → Methyl 3-cyclopentyl-3-[4-[7-(2-trimethylsilylethoxymethyl)pyrrolo[2,3-d]pyrimidin-4-yl]pyrazol-1-yl]prop-2-enoate

HRID 311566Notes

Reaction equation

HRID 311566 reaction equation
[CH3:34][C:35]#[N:36].[CH:23]1([C:28]#[C:29][C:30](=[O:31])[O:32][CH3:33])[CH2:24][CH2:25][CH2:26][CH2:27]1.[ClH:48].[N:37]12[CH2:38][CH2:39][CH2:40][N:41]=[C:42]1[CH2:43][CH2:44][CH2:45][CH2:46][CH2:47]2.[nH:1]1[n:2][cH:3][c:4](-[c:6]2[c:7]3[c:8]([n:9][cH:10][n:11]2)[n:12]([CH2:15][O:16][CH2:17][CH2:18][Si:19]([CH3:20])([CH3:21])[CH3:22])[cH:13][cH:14]3)[cH:5]1>>[n:1]1([C:28]([CH:23]2[CH2:24][CH2:25][CH2:26][CH2:27]2)=[CH:29][C:30](=[O:31])[O:32][CH3:33])[n:2][cH:3][c:4](-[c:6]2[c:7]3[c:8]([n:9][cH:10][n:11]2)[n:12]([CH2:15][O:16][CH2:17][CH2:18][Si:19]([CH3:20])([CH3:21])[CH3:22])[cH:13][cH:14]3)[cH:5]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 6342AcetonitrileHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 426313464-(1H-Pyrazol-4-yl)-7-(2-(trimethylsilyl)ethoxy)methyl-7 H-pyrrolo(2,3-d)-pyrimidineHCID 59420162Methyl 3-cyclopentylprop-2-ynoate

Product 1

HCID 68471115Methyl 3-cyclopentyl-3-[4-[7-(2-trimethylsilylethoxymethyl)pyrrolo[2,3-d]pyrimidin-4-yl]pyrazol-1-yl]prop-2-enoate

Sources & evidence

ORD record
ord-e11d07dfd0f545ab82ddefd774ce1bc5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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