Sodium ion → N-[5-chloro-7-(3-methoxyprop-1-yn-1-yl)-1,3-benzodioxol-4-yl]-7-(3-morpholin-4-ylpropoxy)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine
Reaction equation
[CH3:1][Si:2]([N-:3][Si:4]([CH3:5])([CH3:6])[CH3:7])([CH3:8])[CH3:9].[Cl:16][c:17]1[c:18]([NH2:31])[c:19]2[c:20]([c:24]([C:26]#[C:27][CH2:28][O:29][CH3:30])[cH:25]1)[O:21][CH2:22][O:23]2.[Cl:32][c:33]1[n:34][cH:35][n:36][c:37]2[cH:38][c:39]([O:50][CH2:51][CH2:52][CH2:53][N:54]3[CH2:55][CH2:56][O:57][CH2:58][CH2:59]3)[cH:40][c:41]([O:43][CH:44]3[CH2:45][CH2:46][O:47][CH2:48][CH2:49]3)[c:42]12.[Na+:10].[O:11]1[CH2:12][CH2:13][CH2:14][CH2:15]1.[O:60]=[CH:61][N:62]([CH3:63])[CH3:64]>>[Cl:16][c:17]1[c:18]([NH:31][c:33]2[n:34][cH:35][n:36][c:37]3[cH:38][c:39]([O:50][CH2:51][CH2:52][CH2:53][N:54]4[CH2:55][CH2:56][O:57][CH2:58][CH2:59]4)[cH:40][c:41]([O:43][CH:44]4[CH2:45][CH2:46][O:47][CH2:48][CH2:49]4)[c:42]23)[c:19]2[c:20]([c:24]([C:26]#[C:27][CH2:28][O:29][CH3:30])[cH:25]1)[O:21][CH2:22][O:23]2Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-717a5910c7df4f6297c1ecd891491a21
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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