Tetrahydrofuran → 1-Benzyl-3-(SR)-hydroxymethyl-4-(RS)-(3-thienyl)pyrrolidine
Reaction equation
[Al+3:34].[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH:10]([C:18](=[O:19])[N:20]2[CH:21]([CH2:22][c:23]3[cH:24][cH:25][cH:26][cH:27][cH:28]3)[CH2:29][O:30][C:31]2=[O:32])[CH:11]([c:13]2[cH:14][s:15][cH:16][cH:17]2)[CH2:12]1.[CH2:39]1[O:40][CH2:41][CH2:42][CH2:43]1.[H-:33].[H-:36].[H-:37].[H-:38].[Li+:35]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH:10]([CH2:18][OH:19])[CH:11]([c:13]2[cH:14][s:15][cH:16][cH:17]2)[CH2:12]1Participants
6
Sources & evidence
- ORD record
- ord-ddaaf7cb096743eead13eeab5798f1dc
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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