Tetrahydrofuran → tert-Butyl (1-cyclobutyl-3-oxopropan-2-yl)carbamate

HRID 312149Notes

Reaction equation

HRID 312149 reaction equation
[Al+3:22].[CH:1]1([CH2:5][CH:6]([C:7](=[O:8])[N:9]([O:10][CH3:11])[CH3:12])[NH:13][C:14]([O:15][C:16]([CH3:17])([CH3:18])[CH3:19])=[O:20])[CH2:2][CH2:3][CH2:4]1.[H-:21].[H-:24].[H-:25].[H-:26].[Li+:23].[O:27]1[CH2:28][CH2:29][CH2:30][CH2:31]1>>[CH:1]1([CH2:5][CH:6]([CH:7]=[O:8])[NH:13][C:14]([O:15][C:16]([CH3:17])([CH3:18])[CH3:19])=[O:20])[CH2:2][CH2:3][CH2:4]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 20782733tert-Butyl {3-cyclobutyl-1-[methoxy(methyl)amino]-1-oxopropan-2-yl}carbamate

Product 1

HCID 11579497tert-Butyl (1-cyclobutyl-3-oxopropan-2-yl)carbamate

Sources & evidence

ORD record
ord-5591150e990c475182fa3127b27d3e80
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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