Chloroform → 5-chloro-N-[1-(2,5-difluorophenyl)-3-(1,3-dioxoisoindol-2-yl)propan-2-yl]-4-(2-methylpyrazol-3-yl)thiophene-2-carboxamide

HRID 312414Notes

Reaction equation

HRID 312414 reaction equation
[CH:53]([N:54]([CH2:55][CH3:56])[CH:57]([CH3:58])[CH3:59])([CH3:60])[CH3:61].[CH:62]([Cl:63])([Cl:64])[Cl:65].[Cl:1][c:2]1[c:3](-[c:10]2[cH:11][cH:12][n:13][n:14]2[CH3:15])[cH:4][c:5]([C:7](=[O:8])[OH:9])[s:6]1.[F:39][c:40]1[cH:41][cH:42][cH:43][c:44]([F:45])[c:46]1[CH2:47][CH:48]([C:49]([OH:50])=[O:51])[NH2:52].[NH2:16][CH:17]([CH2:18][N:19]1[C:20](=[O:29])[c:21]2[cH:22][cH:23][cH:24][cH:25][c:26]2[C:27]1=[O:28])[CH2:30][c:31]1[c:32]([F:38])[cH:33][cH:34][c:35]([F:37])[cH:36]1>>[Cl:1][c:2]1[c:3](-[c:10]2[cH:11][cH:12][n:13][n:14]2[CH3:15])[cH:4][c:5]([C:7](=[O:9])[NH:16][CH:17]([CH2:18][N:19]2[C:20](=[O:29])[c:21]3[cH:22][cH:23][cH:24][cH:25][c:26]3[C:27]2=[O:28])[CH2:30][c:31]2[c:32]([F:38])[cH:33][cH:34][c:35]([F:37])[cH:36]2)[s:6]1

Participants

6

Reactant 5

HCID 6212ChloroformHCID 81531DiisopropylethylamineHCID 27370432,6-DifluorophenylalanineHCID 578263895-chloro-4-(1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxylic acidHCID 178510837HCID 178510837, compound

Product 1

HCID 1784817965-chloro-N-[1-(2,5-difluorophenyl)-3-(1,3-dioxoisoindol-2-yl)propan-2-yl]-4-(2-methylpyrazol-3-yl)thiophene-2-carboxamide

Sources & evidence

ORD record
ord-428ec296caa740cbbf848e9e94704297
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

Loading…