N-methyl-2-pyrrolidone → N-(4,4-dimethyl-1,2,3,4-tetrahydro-7-quinolinyl)-2-((1H-pyrazolo[3,4-b]pyridin-4-ylmethyl)amino)-3-pyridinecarboxamide

HRID 312506Notes

Reaction equation

HRID 312506 reaction equation
[CH3:1][C:2]1([CH3:22])[CH2:3][CH2:4][NH:5][c:6]2[cH:7][c:8]([NH:12][C:13]([c:14]3[c:15]([F:20])[n:16][cH:17][cH:18][cH:19]3)=[O:21])[cH:9][cH:10][c:11]21.[CH3:43][N:44]1[CH2:45][CH2:46][CH2:47][C:48]1=[O:49].[CH:34]([N:35]([CH2:36][CH3:37])[CH:38]([CH3:39])[CH3:40])([CH3:41])[CH3:42].[nH:23]1[n:24][cH:25][c:26]2[c:27]1[n:28][cH:29][cH:30][c:31]2[CH2:32][NH2:33]>>[CH3:1][C:2]1([CH3:22])[CH2:3][CH2:4][NH:5][c:6]2[cH:7][c:8]([NH:12][C:13]([c:14]3[c:15]([NH:33][CH2:32][c:31]4[c:26]5[cH:25][n:24][nH:23][c:27]5[n:28][cH:29][cH:30]4)[n:16][cH:17][cH:18][cH:19]3)=[O:21])[cH:9][cH:10][c:11]21

Participants

5

Reactant 4

HCID 13387N-methyl-2-pyrrolidoneHCID 81531DiisopropylethylamineHCID 55285368(1H-Pyrazolo[3,4-b]pyridin-4-yl)methanamineHCID 68908856N-(4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-7-yl)-2-fluoro-nicotinamide

Product 1

HCID 58942003N-(4,4-dimethyl-1,2,3,4-tetrahydro-7-quinolinyl)-2-((1H-pyrazolo[3,4-b]pyridin-4-ylmethyl)amino)-3-pyridinecarboxamide

Sources & evidence

ORD record
ord-faab49bed03d4ff2857fe0c964092c48
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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