Dimethylformamide → 7-(5-Fluoro-2-methyl-4-(1-(tetrahydro-2H-pyran-2-yl)-1H-1,2,4-triazol-3-yl)phenyl)-1-isopropyl-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one
Reaction equation
[Br:19][c:20]1[cH:21][c:22]([F:38])[c:23](-[c:27]2[n:28][n:29]([CH:32]3[O:33][CH2:34][CH2:35][CH2:36][CH2:37]3)[cH:30][n:31]2)[cH:24][c:25]1[CH3:26].[CH3:39][N:40]([CH3:41])[CH:42]=[O:43].[CH:1]([CH3:2])([CH3:3])[N:4]1[C:5](=[O:18])[CH2:6][NH:7][c:8]2[c:9]1[n:10][c:11]([Sn:14]([CH3:15])([CH3:16])[CH3:17])[cH:12][n:13]2.[Pd:44]([Cl:45])[Cl:46].[c:47]1([P:48]([c:49]2[cH:50][cH:51][cH:52][cH:53][cH:54]2)[c:55]2[cH:56][cH:57][cH:58][cH:59][cH:60]2)[cH:61][cH:62][cH:63][cH:64][cH:65]1.[c:66]1([P:67]([c:68]2[cH:69][cH:70][cH:71][cH:72][cH:73]2)[c:74]2[cH:75][cH:76][cH:77][cH:78][cH:79]2)[cH:80][cH:81][cH:82][cH:83][cH:84]1>>[CH:1]([CH3:2])([CH3:3])[N:4]1[C:5](=[O:18])[CH2:6][NH:7][c:8]2[c:9]1[n:10][c:11](-[c:20]1[cH:21][c:22]([F:38])[c:23](-[c:27]3[n:28][n:29]([CH:32]4[O:33][CH2:34][CH2:35][CH2:36][CH2:37]4)[cH:30][n:31]3)[cH:24][c:25]1[CH3:26])[cH:12][n:13]2Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-9ccfce644d8d42cf8e651611d3055e6a
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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