Hydrochloric Acid → 3-(4'-Chloro-6-fluoro-4-methyl-biphenyl-3-yl)-4-hydroxy-8-methoxy-1,8-diazaspiro[4.5]dec-3-en-2-one
Reaction equation
[Br:1][c:2]1[c:3]([F:23])[cH:4][c:5]([CH3:22])[c:6]([C:8]2=[C:12]([OH:13])[C:11]3([NH:10][C:9]2=[O:21])[CH2:14][CH2:15][N:16]([O:19][CH3:20])[CH2:17][CH2:18]3)[cH:7]1.[CH2:41]([CH2:42][O:43][CH3:44])[O:45][CH3:46].[Cl:24][c:25]1[cH:26][cH:27][c:28]([B:31]([OH:32])[OH:33])[cH:29][cH:30]1.[ClH:40].[Na+:34].[Na+:35].[O-:36][C:37](=[O:38])[O-:39].[OH2:124].[cH:47]1[cH:48][cH:49][c:50]([P:51]([Pd:52]([P:53]([c:54]2[cH:55][cH:56][cH:57][cH:58][cH:59]2)([c:60]2[cH:61][cH:62][cH:63][cH:64][cH:65]2)[c:66]2[cH:67][cH:68][cH:69][cH:70][cH:71]2)([P:72]([c:73]2[cH:74][cH:75][cH:76][cH:77][cH:78]2)([c:79]2[cH:80][cH:81][cH:82][cH:83][cH:84]2)[c:85]2[cH:86][cH:87][cH:88][cH:89][cH:90]2)[P:91]([c:92]2[cH:93][cH:94][cH:95][cH:96][cH:97]2)([c:98]2[cH:99][cH:100][cH:101][cH:102][cH:103]2)[c:104]2[cH:105][cH:106][cH:107][cH:108][cH:109]2)([c:110]2[cH:111][cH:112][cH:113][cH:114][cH:115]2)[c:116]2[cH:117][cH:118][cH:119][cH:120][cH:121]2)[cH:122][cH:123]1>>[c:2]1(-[c:28]2[cH:27][cH:26][c:25]([Cl:24])[cH:30][cH:29]2)[c:3]([F:23])[cH:4][c:5]([CH3:22])[c:6]([C:8]2=[C:12]([OH:13])[C:11]3([NH:10][C:9]2=[O:21])[CH2:14][CH2:15][N:16]([O:19][CH3:20])[CH2:17][CH2:18]3)[cH:7]1Participants
9
Reactant 8
Product 1
Sources & evidence
- ORD record
- ord-5340ee477aa04158a3f731903ff6d641
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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