Methanol → Methyl 5-bromo-2-(2-fluorophenylamino)-3,4-difluorobenzoate

HRID 313581Notes

Reaction equation

HRID 313581 reaction equation
[Br:1][c:2]1[c:3]([F:20])[c:4]([F:19])[c:5]([NH:11][c:12]2[c:13]([F:18])[cH:14][cH:15][cH:16][cH:17]2)[c:6]([C:7](=[O:8])[OH:9])[cH:10]1.[CH2:28]1[O:29][CH2:30][CH2:31][CH2:32]1.[CH3:21][Si:22]([CH:23]=[N+:24]=[N-:25])([CH3:26])[CH3:27].[CH3:33][OH:34]>>[Br:1][c:2]1[c:3]([F:20])[c:4]([F:19])[c:5]([NH:11][c:12]2[c:13]([F:18])[cH:14][cH:15][cH:16][cH:17]2)[c:6]([C:7](=[O:8])[O:9][CH3:21])[cH:10]1

Participants

5

Reactant 4

HCID 887MethanolHCID 8028TetrahydrofuranHCID 167693TrimethylsilyldiazomethaneHCID 595193885-Bromo-3,4-difluoro-2-((2-fluorophenyl)amino)benzoic acid

Product 1

HCID 59519391Methyl 5-bromo-2-(2-fluorophenylamino)-3,4-difluorobenzoate

Sources & evidence

ORD record
ord-65ddc667feea4665b3da23cf1dfa48d9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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