Chloride → (3-Benzyloxy-2-ethoxyphenyl)-(1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanol

HRID 314362Notes

Reaction equation

HRID 314362 reaction equation
[CH2:26]([CH3:27])[O:28][c:29]1[c:30]([CH:31]=[O:32])[cH:33][cH:34][cH:35][c:36]1[O:37][CH2:38][c:39]1[cH:40][cH:41][cH:42][cH:43][cH:44]1.[CH:22]([Mg+:23])([CH3:24])[CH3:25].[Cl-:21].[I:1][c:2]1[cH:3][n:4]([Si:11]([CH:12]([CH3:13])[CH3:14])([CH:15]([CH3:16])[CH3:17])[CH:18]([CH3:19])[CH3:20])[c:5]2[n:6][cH:7][cH:8][cH:9][c:10]12.[O:46]1[CH2:47][CH2:48][CH2:49][CH2:50]1.[OH2:45]>>[c:2]1([CH:31]([c:30]2[c:29]([O:28][CH2:26][CH3:27])[c:36]([O:37][CH2:38][c:39]3[cH:40][cH:41][cH:42][cH:43][cH:44]3)[cH:35][cH:34][cH:33]2)[OH:32])[cH:3][n:4]([Si:11]([CH:12]([CH3:13])[CH3:14])([CH:15]([CH3:16])[CH3:17])[CH:18]([CH3:19])[CH3:20])[c:5]2[n:6][cH:7][cH:8][cH:9][c:10]12

Participants

7

Reactant 6

HCID 312ChlorideHCID 962WaterHCID 8028TetrahydrofuranHCID 242292273-Iodo-1-[tris(1-methylethyl)silyl]-1H-pyrrolo[2,3-b]pyridineHCID 580866452-Ethoxy-3-benzyloxybenzaldehydeHCID 178461726HCID 178461726, compound

Product 1

HCID 66679415(3-Benzyloxy-2-ethoxyphenyl)-(1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanol

Sources & evidence

ORD record
ord-ef96caba216a4952989dfbafbea2b1ce
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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