Tetrahydrofuran → 4-[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}-phenyl)-1,3-thiazol-2-yl]tetrahydro-2H-thiopyran-4-ol
Reaction equation
[CH2:39]1[O:40][CH2:41][CH2:42][CH2:43]1.[CH3:1][c:2]1[cH:3][c:4]([NH:13][c:14]2[n:15][cH:16][cH:17][c:18]([C:20]([F:21])([F:22])[F:23])[n:19]2)[cH:5][c:6](-[c:8]2[cH:9][n:10][cH:11][s:12]2)[cH:7]1.[CH:24]([N-:25][CH:26]([CH3:27])[CH3:28])([CH3:29])[CH3:30].[Li+:31].[S:32]1[CH2:33][CH2:34][C:35](=[O:38])[CH2:36][CH2:37]1>>[CH3:1][c:2]1[cH:3][c:4]([NH:13][c:14]2[n:15][cH:16][cH:17][c:18]([C:20]([F:21])([F:22])[F:23])[n:19]2)[cH:5][c:6](-[c:8]2[cH:9][n:10][c:11]([C:35]3([OH:38])[CH2:34][CH2:33][S:32][CH2:37][CH2:36]3)[s:12]2)[cH:7]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-5025ec1394cd47b49c647d02e149c774
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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