Acetate → 4-(4-Chloro-2-fluorophenoxy)-6-methoxy-7-(2-(tert-butoxycarbonyl)vinyl)quinazoline

HRID 314651Notes

Reaction equation

HRID 314651 reaction equation
[C:8]([CH:9]=[CH2:10])(=[O:11])[O:12][C:13]([CH3:14])([CH3:15])[CH3:16].[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[CH2:6][CH3:7].[Cl:33][c:34]1[cH:35][c:36]([F:61])[c:37]([O:38][c:39]2[n:40][cH:41][n:42][c:43]3[cH:44][c:45]([O:51][S:52]([C:53]([F:54])([F:55])[F:56])(=[O:57])=[O:58])[c:46]([O:49][CH3:50])[cH:47][c:48]23)[cH:59][cH:60]1.[O-:68][C:69]([CH3:70])=[O:71].[O-:72][C:73]([CH3:74])=[O:75].[O:62]=[CH:63][N:64]([CH3:65])[CH3:66].[Pd+2:67].[c:17]1([CH:18]([c:19]2[cH:20][cH:21][cH:22][cH:23][cH:24]2)[CH2:25][CH2:26][PH2:27])[cH:28][cH:29][cH:30][cH:31][cH:32]1>>[C:8]([CH:9]=[CH:10][c:45]1[cH:44][c:43]2[n:42][cH:41][n:40][c:39]([O:38][c:37]3[c:36]([F:61])[cH:35][c:34]([Cl:33])[cH:60][cH:59]3)[c:48]2[cH:47][c:46]1[O:49][CH3:50])(=[O:11])[O:12][C:13]([CH3:14])([CH3:15])[CH3:16]

Participants

8

Reactant 7

HCID 175Acetate2×HCID 6228DimethylformamideHCID 8471TriethylamineHCID 15458tert-Butyl acrylateHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 220308424-(4-Chloro-2-fluorophenoxy)-6-methoxy-7-(trifluoromethylsulphonyloxy)quinazolineHCID 53436545Diphenylpropyl phosphine

Product 1

HCID 540046344-(4-Chloro-2-fluorophenoxy)-6-methoxy-7-(2-(tert-butoxycarbonyl)vinyl)quinazoline

Sources & evidence

ORD record
ord-80d7c1884c0a4e04999d389f0434bac7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

Loading…