Hydrochloric Acid → 4-(Piperazine-1-sulfonyl)morpholine hydrochloride

HRID 31511Notes

Reaction equation

HRID 31511 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([S:14]([N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)(=[O:16])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:23]>O1CCOCC1>[ClH:23].[N:11]1([S:14]([N:17]2[CH2:18][CH2:19][O:20][CH2:21][CH2:22]2)(=[O:16])=[O:15])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69273755HCID 69273755, compound

Product 1

HCID 428835964-(Piperazine-1-sulfonyl)morpholine hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

4-(Morpholine-4-sulfonyl)-piperazine-1-carboxylic acid tert-butyl ester (39 mg) was dissolved in 4 mL of dioxane, and 4 mL of 4.0 M hydrochloric acid in dioxane was added. After standing overnight at ambient temperature, the solvent was removed to give 4-(piperazine-1-sulfonyl)-morpholine hydrochloride as a white solid.

Workup

  1. customthe solvent was removed

Sources & evidence

ORD record
ord-c72c463ce5b74f8b83f67fa8a8cd7319
Source dataset
uspto-grants-2008_09
Patent number
US07425638B2

Reaction notes

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