Phosphorus oxychloride → Ethyl 3-(4-iodophenyl)-3-chloro-2-ethoxycarbonylacrylate

HRID 315328Notes

Reaction equation

HRID 315328 reaction equation
[CH:21]([N:22]([CH:23]([CH3:24])[CH3:25])[CH2:26][CH3:27])([CH3:28])[CH3:29].[I:1][c:2]1[cH:3][cH:4][c:5]([C:6](=[O:7])[CH:8]([C:9](=[O:10])[O:11][CH2:12][CH3:13])[C:14](=[O:15])[O:16][CH2:17][CH3:18])[cH:19][cH:20]1.[P:30]([Cl:31])([Cl:32])([Cl:33])=[O:34]>>[I:1][c:2]1[cH:3][cH:4][c:5]([C:6](=[C:8]([C:9](=[O:10])[O:11][CH2:12][CH3:13])[C:14](=[O:15])[O:16][CH2:17][CH3:18])[Cl:32])[cH:19][cH:20]1

Participants

4

Reactant 3

HCID 24813Phosphorus oxychlorideHCID 81531DiisopropylethylamineHCID 53643535Diethyl 4-iodobenzoylmalonate

Product 1

HCID 21837631Ethyl 3-(4-iodophenyl)-3-chloro-2-ethoxycarbonylacrylate

Sources & evidence

ORD record
ord-e2263a578b244b9685f412e4274bd2a9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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