Dimethylformamide → 4-(6-{5-Chloro-4-[2-(propane-2-sulfonyl)-phenylamino]-pyrimidin-2-ylamino}-5-isopropoxy-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-1-carboxylic acid ethyl ester
Reaction equation
[CH3:42][CH2:43][N:44]([CH2:45][CH3:46])[CH2:47][CH3:48].[Cl:1][c:2]1[c:3]([NH:29][c:30]2[c:31]([S:36](=[O:37])(=[O:38])[CH:39]([CH3:40])[CH3:41])[cH:32][cH:33][cH:34][cH:35]2)[n:4][c:5]([NH:8][c:9]2[c:10]([O:25][CH:26]([CH3:27])[CH3:28])[cH:11][c:12]3[c:16]([cH:17]2)[C:15](=[O:18])[N:14]([CH:19]2[CH2:20][CH2:21][NH:22][CH2:23][CH2:24]2)[CH2:13]3)[n:6][cH:7]1.[Cl:49][C:50](=[O:51])[O:52][CH2:53][CH3:54].[O:55]=[CH:56][N:57]([CH3:58])[CH3:59]>>[Cl:1][c:2]1[c:3]([NH:29][c:30]2[c:31]([S:36](=[O:37])(=[O:38])[CH:39]([CH3:40])[CH3:41])[cH:32][cH:33][cH:34][cH:35]2)[n:4][c:5]([NH:8][c:9]2[c:10]([O:25][CH:26]([CH3:27])[CH3:28])[cH:11][c:12]3[c:16]([cH:17]2)[C:15](=[O:18])[N:14]([CH:19]2[CH2:20][CH2:21][N:22]([C:50](=[O:51])[O:52][CH2:53][CH3:54])[CH2:23][CH2:24]2)[CH2:13]3)[n:6][cH:7]1Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-a4f0baf2134d4a8f96858d35d854dbd9
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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