Acetic Acid → (4,4-Difluoropiperidin-1-yl)(phenyl)acetonitrile
Reaction equation
[C-:17]#[N:18].[CH3:20][C:21](=[O:22])[OH:23].[CH3:24][OH:25].[CH:1](=[O:2])[c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1.[F:9][C:10]1([F:16])[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]1.[Na+:19]>>[CH:1]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)([N:13]1[CH2:12][CH2:11][C:10]([F:9])([F:16])[CH2:15][CH2:14]1)[C:17]#[N:18]Participants
7
Sources & evidence
- ORD record
- ord-818c2771025b45c0bd68297aa222b198
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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