Tetrahydrofuran → 4,4,4-Trifluoro-3-hydroxy-3-methyl-1-[4-(1-pyrrolidinylsulfonyl)phenyl]but-1-yne

HRID 317057Notes

Reaction equation

HRID 317057 reaction equation
[CH2:17]([Li:18])[CH2:19][CH2:20][CH3:21].[F:22][C:23]([C:24]([CH3:25])=[O:26])([F:27])[F:28].[N:1]1([S:6](=[O:7])(=[O:8])[c:9]2[cH:10][cH:11][c:12]([C:15]#[CH:16])[cH:13][cH:14]2)[CH2:2][CH2:3][CH2:4][CH2:5]1.[O:29]1[CH2:30][CH2:31][CH2:32][CH2:33]1>>[N:1]1([S:6](=[O:7])(=[O:8])[c:9]2[cH:10][cH:11][c:12]([C:15]#[C:16][C:24]([C:23]([F:22])([F:27])[F:28])([CH3:25])[OH:26])[cH:13][cH:14]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 9871Methyl trifluoromethyl ketoneHCID 214691194-(1-Pyrrolidinylsulfonyl)phenylacetyleneHCID 178418339Butyllithium

Product 1

HCID 214691154,4,4-Trifluoro-3-hydroxy-3-methyl-1-[4-(1-pyrrolidinylsulfonyl)phenyl]but-1-yne

Sources & evidence

ORD record
ord-c6456db642604826b5bd4d69725bb987
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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