Dimethylformamide → tert-Butyl 3-(2-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-5-methylpyridin-4-yl)benzoate

HRID 317277Notes

Reaction equation

HRID 317277 reaction equation
[CH3:43][CH2:44][N:45]([CH2:46][CH3:47])[CH2:48][CH3:49].[CH3:53][N:54]([CH3:55])[CH:56]=[O:57].[Cl:50][CH2:51][Cl:52].[F:1][C:2]1([F:17])[O:3][c:4]2[c:5]([cH:7][cH:8][c:9]([C:11]3([C:14](=[O:15])[OH:16])[CH2:12][CH2:13]3)[cH:10]2)[O:6]1.[NH2:22][c:23]1[n:24][cH:25][c:26]([CH3:42])[c:27](-[c:29]2[cH:30][c:31]([C:32](=[O:33])[O:34][C:35]([CH3:36])([CH3:37])[CH3:38])[cH:39][cH:40][cH:41]2)[cH:28]1.[S:18]([Cl:19])([Cl:20])=[O:21]>>[F:1][C:2]1([F:17])[O:3][c:4]2[c:5]([cH:7][cH:8][c:9]([C:11]3([C:14](=[O:16])[NH:22][c:23]4[n:24][cH:25][c:26]([CH3:42])[c:27](-[c:29]5[cH:30][c:31]([C:32](=[O:33])[O:34][C:35]([CH3:36])([CH3:37])[CH3:38])[cH:39][cH:40][cH:41]5)[cH:28]4)[CH2:12][CH2:13]3)[cH:10]2)[O:6]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 8471TriethylamineHCID 24386Thionyl ChlorideHCID 442061031-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropanecarboxylic acidHCID 57895160Tert-butyl 3-(2-amino-5-methylpyridin-4-yl)benzoate

Product 1

HCID 57895169tert-Butyl 3-(2-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-5-methylpyridin-4-yl)benzoate

Sources & evidence

ORD record
ord-7631ffd6acca45639b9d8ee9ed2440c5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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