Acetate → 1-(2-methylpropyl)-8-(2-pyridin-4-ylvinyl)-1H-imidazo[4,5-c]-quinolin-4-amine

HRID 317295Notes

Reaction equation

HRID 317295 reaction equation
[Br:1][c:2]1[cH:3][c:4]2[c:5]3[c:6]([c:7]([NH2:12])[n:8][c:9]2[cH:10][cH:11]1)[n:13][cH:14][n:15]3[CH2:16][CH:17]([CH3:18])[CH3:19].[CH3:47][CH2:48][N:49]([CH2:50][CH3:51])[CH2:52][CH3:53].[CH3:54][C:55]#[N:56].[CH:20](=[CH2:21])[c:22]1[cH:23][cH:24][n:25][cH:26][cH:27]1.[O-:58][C:59]([CH3:60])=[O:61].[O-:62][C:63]([CH3:64])=[O:65].[Pd+2:57].[c:28]1([P:29]([c:30]2[cH:31][cH:32][cH:33][cH:34][cH:35]2)[c:36]2[cH:37][cH:38][cH:39][cH:40][cH:41]2)[cH:42][cH:43][cH:44][cH:45][cH:46]1>>[c:2]1([CH:21]=[CH:20][c:22]2[cH:23][cH:24][n:25][cH:26][cH:27]2)[cH:3][c:4]2[c:5]3[c:6]([c:7]([NH2:12])[n:8][c:9]2[cH:10][cH:11]1)[n:13][cH:14][n:15]3[CH2:16][CH:17]([CH3:18])[CH3:19]

Participants

8

Reactant 7

HCID 175Acetate2×HCID 6342AcetonitrileHCID 75024-VinylpyridineHCID 8471TriethylamineHCID 11776TriphenylphosphineHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 111745978-bromo-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine

Product 1

HCID 688187741-(2-methylpropyl)-8-(2-pyridin-4-ylvinyl)-1H-imidazo[4,5-c]-quinolin-4-amine

Sources & evidence

ORD record
ord-ebd71becd9ad415c9c4e98fc051324bd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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