Dichloromethane → Piperazine,1-[5-(1h-benzo[d]imidazol-2-yl)-2-pyridinyl]-4-[2-(trifluoromethyl)benzoyl]-

HRID 317552Notes

Reaction equation

HRID 317552 reaction equation
[CH2:22]1[O:23][CH2:24][CH2:25][CH2:26]1.[CH3:43][CH2:44][N:45]([CH2:46][CH3:47])[CH2:48][CH3:49].[Cl:27][CH2:28][Cl:29].[F:30][C:31]([c:32]1[c:33]([C:34](=[O:35])[Cl:36])[cH:37][cH:38][cH:39][cH:40]1)([F:41])[F:42].[N:1]1([c:7]2[cH:8][cH:9][c:10](-[c:13]3[n:14][c:15]4[c:16]([nH:17]3)[cH:18][cH:19][cH:20][cH:21]4)[cH:11][n:12]2)[CH2:2][CH2:3][NH:4][CH2:5][CH2:6]1>>[N:1]1([c:7]2[cH:8][cH:9][c:10](-[c:13]3[n:14][c:15]4[c:16]([nH:17]3)[cH:18][cH:19][cH:20][cH:21]4)[cH:11][n:12]2)[CH2:2][CH2:3][N:4]([C:34]([c:33]2[c:32]([C:31]([F:30])([F:41])[F:42])[cH:40][cH:39][cH:38][cH:37]2)=[O:35])[CH2:5][CH2:6]1

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 675612-(Trifluoromethyl)benzoyl chlorideHCID 675232322-(6-Piperazin-1-YL-pyridin-3-YL)-1H-benzoimidazole

Product 1

HCID 11712097Piperazine,1-[5-(1h-benzo[d]imidazol-2-yl)-2-pyridinyl]-4-[2-(trifluoromethyl)benzoyl]-

Sources & evidence

ORD record
ord-2419a3e6b7594cc98eef45d2de11da09
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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