Hydrochloric Acid → [4-(2,4-Dichlorophenyl)-5-piperazinylpyrimidin-2-yl]{2-[(5-nitro(2-pyridyl))amino]ethyl}amine

HRID 31788Notes

Reaction equation

HRID 31788 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:14]([N:15]2[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]2)=[CH:13][N:12]=[C:11]([NH:28][CH2:29][CH2:30][NH:31][C:32]2[CH:37]=[CH:36][C:35]([N+:38]([O-:40])=[O:39])=[CH:34][N:33]=2)[N:10]=1.Cl>CO>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:14]([N:15]2[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]2)=[CH:13][N:12]=[C:11]([NH:28][CH2:29][CH2:30][NH:31][C:32]2[CH:37]=[CH:36][C:35]([N+:38]([O-:40])=[O:39])=[CH:34][N:33]=2)[N:10]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22142789HCID 22142789, compound

Product 1

HCID 9805529[4-(2,4-Dichlorophenyl)-5-piperazinylpyrimidin-2-yl]{2-[(5-nitro(2-pyridyl))amino]ethyl}amine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1 mmol of tert-butyl 4-[4-(2,4-dichlorophenyl)-2-({2-[(5-nitro(2-pyridyl))amino]-ethyl}amino)pyrimidin-5-yl]piperazinecarboxylate is heated to 60° C. 3M HCl in MeOH for one hour and concentrated in vacuo to obtain [4-(2,4-dichlorophenyl)-5-piperazinylpyrimidin-2-yl]{2-[(5-nitro(2-pyridyl))amino]ethyl}amine.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-51038916561e49c192cae502128beeb2
Source dataset
uspto-grants-2008_09
Patent number
US07425557B2

Reaction notes

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