Hydrochloric Acid → 2,4-Diamino-5-chloro-6-[5-chloro-2-(pyridin-2-ylmethoxy)phenyl]quinazoline

HRID 318064Notes

Reaction equation

HRID 318064 reaction equation
[C:31](=[O:32])([O-:33])[O-:34].[CH3:37][N:38]([CH3:39])[CH:40]=[O:41].[ClH:22].[K+:35].[K+:36].[NH2:1][c:2]1[n:3][c:4]2[cH:5][cH:6][c:7](-[c:14]3[c:15]([OH:21])[cH:16][cH:17][c:18]([Cl:20])[cH:19]3)[c:8]([Cl:13])[c:9]2[c:10]([NH2:12])[n:11]1.[n:23]1[c:24]([CH2:29][Cl:30])[cH:25][cH:26][cH:27][cH:28]1>>[NH2:1][c:2]1[n:3][c:4]2[cH:5][cH:6][c:7](-[c:14]3[c:15]([O:21][CH2:29][c:24]4[n:23][cH:28][cH:27][cH:26][cH:25]4)[cH:16][cH:17][c:18]([Cl:20])[cH:19]3)[c:8]([Cl:13])[c:9]2[c:10]([NH2:12])[n:11]1

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 813Potassium Cation2×HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 23393Picolyl chlorideHCID 543690952,4-Diamino-5-chloro-6-(5-chloro-2-hydroxyphenyl)quinazoline

Product 1

HCID 541271462,4-Diamino-5-chloro-6-[5-chloro-2-(pyridin-2-ylmethoxy)phenyl]quinazoline

Sources & evidence

ORD record
ord-698921fe5e5d4df89a803eab4030b26e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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