反应详情

温度

50 °C

To a solution of (2-bromo-ethoxy)-carbamic acid tert-butyl ester (252 mg, 1.05 mmol) in DMF (2 mL) at room temperature is added morpholine (0.14 mL, 1.6 mmol). The reaction mixture is stirred for 7 hours at 50° C. The reaction mixture is diluted with EtOAc, and washed with water. The organic layer is dried over MgSO4, filtered, concentrated, and purified by flash chromatography (2% MeOH in CH2Cl2) to give the desired product (118 mg, 46%): MS APCI (+) m/z 247 detected.

1. washwashed with water
2. dry with materialThe organic layer is dried over MgSO4
3. filtrationfiltered
4. concentrationconcentrated
5. custompurified by flash chromatography (2% MeOH in CH2Cl2)