Ethyl Acetate → 6-(2,4-Difluorophenoxy)-8-ethyl-2-(3-hydroxy-tetrahydro-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8h)-one
Reaction equation
[CH3:38][CH2:39][O:40][C:41](=[O:42])[CH3:43].[CH3:44][N:45]1[CH2:46][CH2:47][CH2:48][C:49]1=[O:50].[F:1][c:2]1[c:3]([O:4][c:5]2[cH:6][c:7]3[c:8]([n:9][c:10]([NH:13][CH:14]4[CH2:15][CH2:16][O:17][CH2:18][CH2:19]4)[n:11][cH:12]3)[n:20]([CH2:23][CH3:24])[c:21]2=[O:22])[cH:25][cH:26][c:27]([F:29])[cH:28]1.[NH2:30][CH:31]1[CH2:32][CH2:33][O:34][CH2:35][CH:36]1[OH:37]>>[F:1][c:2]1[c:3]([O:4][c:5]2[cH:6][c:7]3[c:8]([n:9][c:10]([NH:13][CH:14]4[CH:15]([OH:34])[CH2:16][O:17][CH2:18][CH2:19]4)[n:11][cH:12]3)[n:20]([CH2:23][CH3:24])[c:21]2=[O:22])[cH:25][cH:26][c:27]([F:29])[cH:28]1Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-40ebd9b3943f459983f4f0105f8de7a8
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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