Hydrochloric Acid → 1-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperidin-4-one

HRID 321285Notes

Reaction equation

HRID 321285 reaction equation
[CH2:37]1[O:38][CH2:39][CH2:40][O:41][CH2:42]1.[CH3:31][CH2:32][O:33][C:34]([CH3:35])=[O:36].[Cl:1][c:2]1[n:3][c:4]([N:22]2[CH2:23][CH2:24][O:25][CH2:26][CH2:27]2)[c:5]2[c:6]([n:7]1)[cH:8][c:9]([CH2:11][N:12]1[CH2:13][CH2:14][C:15]3([O:16][CH2:19][CH2:18][O:17]3)[CH2:20][CH2:21]1)[s:10]2.[ClH:28].[Na+:30].[OH-:29]>>[Cl:1][c:2]1[n:3][c:4]([N:22]2[CH2:23][CH2:24][O:25][CH2:26][CH2:27]2)[c:5]2[c:6]([n:7]1)[cH:8][c:9]([CH2:11][N:12]1[CH2:13][CH2:14][C:15](=[O:16])[CH2:20][CH2:21]1)[s:10]2

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 923Sodium ionHCID 961HydroxideHCID 8857Ethyl AcetateHCID 312751,4-DioxaneHCID 581170818-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-1,4-dioxa-8-aza-spiro[4.5]decane

Product 1

HCID 581171371-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperidin-4-one

Sources & evidence

ORD record
ord-83f77eaac6b140b09bf8d5b9d05fb476
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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