Hydrochloric Acid → 5-(6-(2-propylindoline-1-carbonyl)pyrimidin-4-ylamino)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

HRID 321348Notes

Reaction equation

HRID 321348 reaction equation
[CH3:42][CH:43]([OH:44])[CH2:45][CH2:46][CH3:47].[Cl:2][c:3]1[cH:4][c:5]([C:9](=[O:10])[N:11]2[CH:12]([CH2:20][CH2:21][CH3:22])[CH2:13][c:14]3[cH:15][cH:16][cH:17][cH:18][c:19]32)[n:6][cH:7][n:8]1.[ClH:1].[NH2:23][c:24]1[cH:25][c:26]2[c:30]([cH:31][cH:32]1)[CH2:29][C:28]1([CH2:27]2)[C:33](=[O:41])[NH:34][c:35]2[n:36][cH:37][cH:38][cH:39][c:40]21>>[c:3]1([NH:23][c:24]2[cH:25][c:26]3[c:30]([cH:31][cH:32]2)[CH2:29][C:28]2([CH2:27]3)[C:33](=[O:41])[NH:34][c:35]3[n:36][cH:37][cH:38][cH:39][c:40]32)[cH:4][c:5]([C:9](=[O:10])[N:11]2[CH:12]([CH2:20][CH2:21][CH3:22])[CH2:13][c:14]3[cH:15][cH:16][cH:17][cH:18][c:19]32)[n:6][cH:7][n:8]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 223862-PentanolHCID 58117516(6-Chloro-pyrimidin-4-yl)-(2-propyl-2,3-dihydro-indol-1-yl)-methanoneHCID 591667225-amino-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Product 1

HCID 498036525-(6-(2-propylindoline-1-carbonyl)pyrimidin-4-ylamino)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Sources & evidence

ORD record
ord-f876f44555334dbab9dc5e377176911a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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