Dimethylformamide → 6-{2-[4-(4-methoxy-benzothiazole-2-carbonyl)-piperidin-1-yl]-acetyl}-4H-benzo[1,4]oxazin-3-one

HRID 321357Notes

Reaction equation

HRID 321357 reaction equation
[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]2[c:8]1[n:9][c:10]([C:12](=[O:13])[CH:14]1[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]1)[s:11]2.[CH:35]([N:36]([CH2:37][CH3:38])[CH:39]([CH3:40])[CH3:41])([CH3:42])[CH3:43].[Cl:20][CH2:21][C:22](=[O:23])[c:24]1[cH:25][cH:26][c:27]2[c:28]([cH:34]1)[NH:29][C:30](=[O:33])[CH2:31][O:32]2.[O:44]=[CH:45][N:46]([CH3:47])[CH3:48]>>[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]2[c:8]1[n:9][c:10]([C:12](=[O:13])[CH:14]1[CH2:15][CH2:16][N:17]([CH2:21][C:22](=[O:23])[c:24]3[cH:25][cH:26][c:27]4[c:28]([cH:34]3)[NH:29][C:30](=[O:33])[CH2:31][O:32]4)[CH2:18][CH2:19]1)[s:11]2

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 81531DiisopropylethylamineHCID 27644586-(2-chloroacetyl)-3,4-dihydro-2H-1,4-benzoxazin-3-oneHCID 67315952(4-Methoxy-benzothiazol-2-yl)-piperidin-4-yl-methanone

Product 1

HCID 119990446-{2-[4-(4-methoxy-benzothiazole-2-carbonyl)-piperidin-1-yl]-acetyl}-4H-benzo[1,4]oxazin-3-one

Sources & evidence

ORD record
ord-57b8175823104cd4b2fc048df00fd125
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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