Methanol → HCID 59769422, compound

HRID 32151Notes

Reaction equation

HRID 32151 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([N:20]3[CH2:25][CH2:24][CH:23]([O:26][CH3:27])[CH2:22][CH2:21]3)=[CH:16][C:15]=2[C:28]2[CH2:33][CH2:32][C:31]3([CH2:38][CH2:37][CH2:36][CH2:35][CH2:34]3)[CH2:30][CH:29]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].CO.C(OCC)(=O)C>O1CCCC1>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][N:11]([C:14]2[CH:19]=[CH:18][C:17]([N:20]3[CH2:25][CH2:24][CH:23]([O:26][CH3:27])[CH2:22][CH2:21]3)=[CH:16][C:15]=2[CH:28]2[CH2:29][CH2:30][C:31]3([CH2:34][CH2:35][CH2:36][CH2:37][CH2:38]3)[CH2:32][CH2:33]2)[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 3

HCID 887Methanol2×HCID 8857Ethyl AcetateHCID 59769388HCID 59769388, compound

Product 1

HCID 59769422HCID 59769422, compoundYield 98.3%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

4-[4-(4-Methoxypiperidin-1-yl)-2-spiro[5.5]undec-2-en-3-ylphenyl]piperazine-1-carb oxylic acid t-butyl ester (524 mg, 1.0 mmol) prepared in Example (39f) was used as the starting material. A mixed solution of methanol, tetrahydrofuran and ethyl acetate was used instead of a mixed solvent of methanol and tetrahydrofuran for reaction in a manner similar to Example (8a) and treated in a similar manner, to give 517 mg of the title compound as a colorless solid.

Workup

  1. additiontreated in a similar manner

Sources & evidence

ORD record
ord-e533b99363bc4fe99f1fac062275a42d
Source dataset
uspto-grants-2008_09
Patent number
US07425554B2

Reaction notes

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