Hydrochloric Acid → 1-(2-Methylsulfanylethyl)-4-[2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine hydrochloride

HRID 32166Notes

Reaction equation

HRID 32166 reaction equation
[CH3:1][S:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH:17]2[CH2:22][C:21]([CH3:24])([CH3:23])[CH2:20][C:19]([CH3:26])([CH3:25])[CH2:18]2)[CH2:7][CH2:6]1.[ClH:27].C(OCC)(=O)C>ClCCl>[ClH:27].[CH3:1][S:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH:17]2[CH2:22][C:21]([CH3:24])([CH3:23])[CH2:20][C:19]([CH3:26])([CH3:25])[CH2:18]2)[CH2:7][CH2:6]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 231427851-(2-Methylsulfanylethyl)-4-[2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine

Product 1

HCID 231430791-(2-Methylsulfanylethyl)-4-[2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine hydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

After dissolving 1-(2-methylsulfanylethyl)-4-[2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine (22 mg, 0.0588 mmol) in dichloromethane (1.5 mL), a 4N solution of hydrogen chloride in ethyl acetate (0.0294 mL, 0.1175 mmol) was added. The solution was concentrated, diethyl ether was added to the obtained residue to produce a solid, and the supernatant diethyl ether solution was removed. The resultant solid was dried under reduced pressure to give 14 mg of the title compound as a colorless solid.

Workup

  1. concentrationThe solution was concentrated
  2. additiondiethyl ether was added to the obtained residue
  3. customto produce a solid
  4. customthe supernatant diethyl ether solution was removed
  5. customThe resultant solid was dried under reduced pressure

Sources & evidence

ORD record
ord-5dc8406c2d2b41b3b3c9c8feca7a2279
Source dataset
uspto-grants-2008_09
Patent number
US07425554B2

Reaction notes

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