Chloride → 1-Acetyl-4-(2',4'-difluorobenzoyl)piperidine

HRID 321680Notes

Reaction equation

HRID 321680 reaction equation
[Al+3:26].[C:1]([CH3:2])(=[O:3])[N:4]1[CH2:5][CH2:6][CH:7]([C:10](=[O:11])[OH:12])[CH2:8][CH2:9]1.[Cl-:25].[Cl-:27].[Cl-:28].[Cl-:29].[Cl:31][CH:32]([Cl:33])[CH3:34].[ClH:30].[F:17][c:18]1[cH:19][cH:20][cH:21][c:22]([F:23])[cH:24]1.[S:13]([Cl:14])([Cl:15])=[O:16]>>[C:1]([CH3:2])(=[O:3])[N:4]1[CH2:5][CH2:6][CH:7]([C:10](=[O:12])[c:19]2[c:18]([F:17])[cH:24][c:22]([F:23])[cH:21][cH:20]2)[CH2:8][CH2:9]1

Participants

8

Reactant 7

HCID 312Chloride4×HCID 313Hydrochloric AcidHCID 63651,1-DichloroethaneHCID 97411,3-DifluorobenzeneHCID 24386Thionyl ChlorideHCID 104727Aluminum CationHCID 1172551-Acetylpiperidine-4-carboxylic acid

Product 1

HCID 27407071-Acetyl-4-(2',4'-difluorobenzoyl)piperidine

Sources & evidence

ORD record
ord-912f5f90c8de42e08b16bbef372a26c9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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