反应详情

To a stirred solution of 3-(4,4-diphenylpiperidin-1-yl)propionitrile (2.00 g, 6.89 mmol, 1.0 equiv) in anhydrous THF (20 mL) under argon was added a solution of BH3 in THF (1.0M, 24.1 mL, 24 mmol, 3.5 equiv) at room temperature. The mixture was refluxed for 4.5 hours and then cooled to room temperature. Aqueous HCl (6N, 50 mL) was added and stirring was continued for 1 hour. The mixture was basified to pH 9 by addition of 6N aq. NaOH, extracted 3 times with CH2Cl2, dried over MgSO4 and concentrated.

1. temperatureThe mixture was refluxed for 4.5 hours
2. extractionextracted 3 times with CH2Cl2
3. dry with materialdried over MgSO4
4. concentrationconcentrated