反应详情

To a stirred solution of 3-(4-phenylpiperidin-1-yl)propionitrile (5.1 g, 24 mmol, 1.0 equiv) in anhydrous THF (20 mL) under argon was added a solution of BH3 in THF (1.0M, 83 mL, 83 mmol, 3.5 equiv) at room temperature. The mixture was refluxed for 4.5 hours and then cooled to room temperature. Aqueous HCl (6N, 130 mL) was added and stirring was continued for 2 hours at 50-70° C. The mixture was basified to pH 9 by addition of 6N aq. NaOH and extracted with EtOAc (100 mL) and CH2Cl2 (3×100 mL). The combined organic solutions were dried over MgSO4 and concentrated. The residue was dissolved in CH2Cl2 (20 mL) and treated with HCl in ether (1.0M, 50 mL). The solvents were removed, ether (250 mL) was added, the mixture was filtered, and the filter cake was washed with ether. Water (60 mL) was added to the resulting white solid, the pH was adjusted to 10-11 with 1M NaOH, and the aqueous phase was extracted three times with CH2Cl2. Drying over MgSO4 followed by removal of solvents gave 4.5 g (87%) of pure product (light brown solid), which was characterized spectroscopically.

1. temperatureThe mixture was refluxed for 4.5 hours
2. extractionextracted with EtOAc (100 mL) and CH2Cl2 (3×100 mL)
3. dry with materialThe combined organic solutions were dried over MgSO4
4. concentrationconcentrated
5. dissolutionThe residue was dissolved in CH2Cl2 (20 mL)
6. additiontreated with HCl in ether (1.0M, 50 mL)
7. customThe solvents were removed
8. additionether (250 mL) was added
9. filtrationthe mixture was filtered
10. washthe filter cake was washed with ether
11. additionWater (60 mL) was added to the resulting white solid
12. extractionthe aqueous phase was extracted three times with CH2Cl2
13. dry with materialDrying over MgSO4
14. customfollowed by removal of solvents