Sodium borohydride → HCID 18673021, Verbindung

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Reaktionsgleichung

[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[S:7][C:8]([C:11](OCC)=[O:12])=[CH:9][N:10]=1.[BH4-].[Na+]>>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[S:7][C:8]([CH2:11][OH:12])=[CH:9][N:10]=1

Komponenten

Edukt 2

HCID 4311764Sodium borohydride

HCID 22009660Ethyl 2-(2-thienyl)-5-thiazolecarboxylate

Produkt 1

HCID 18673021HCID 18673021, VerbindungAusbeute 94 %

Versuchsvorschrift

In substantially the same manner as in Reference Example 111, ethyl 2-(2-thienyl)-5-thiazolecarboxylate was subjected to reduction with sodium borohydride to obtain 2-(2-thienyl)-5-thiazolylmethanol. The yield was 94%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 89-90° C.

Quellen und Nachweise

ORD-Eintrag: ord-76174db9c9b2470cb97e1e3ad0d087ff
Quelldatensatz: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06211215B1

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