反应详情

To trans-1-(2-chloromethylcyclopropylmethyl)-4-[2-(3,3,5,5-tetramethylcyclohexyl)-phenyl]piperazine (19 mg) produced in Example (94a) dissolved in dichloromethane was added a 4N solution of hydrogen chloride in ethyl acetate. Nitrogen was then blown to the solution to remove the solvent. Diethyl ether was added to the obtained residue to produce a solid, which was then triturated by sonication. The supernatant diethyl ether solution was removed and the obtained solid residue was dried by blowing nitrogen, to give 22 mg of the title compound as a light red solid.

1. customto remove the solvent
2. additionDiethyl ether was added to the obtained residue
3. customto produce a solid, which
4. customwas then triturated by sonication
5. customThe supernatant diethyl ether solution was removed
6. customthe obtained solid residue was dried