Phenylboronic Acid → HCID 22009774, compound

HRID 322451Notes

Reaction equation

HRID 322451 reaction equation
Br[C:2]1[O:6][C:5]([C:7]2[O:8][CH:9]=[C:10]([CH2:12][O:13][C:14]3[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][CH2:22][N:23]4[CH:27]=[CH:26][N:25]=[CH:24]4)=[CH:16][CH:15]=3)[N:11]=2)=[CH:4][CH:3]=1.[C:28]1(B(O)O)[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>>[N:23]1([CH2:22][CH2:21][CH2:20][C:17]2[CH:18]=[CH:19][C:14]([O:13][CH2:12][C:10]3[N:11]=[C:7]([C:5]4[O:6][C:2]([C:28]5[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=5)=[CH:3][CH:4]=4)[O:8][CH:9]=3)=[CH:15][CH:16]=2)[CH:27]=[CH:26][N:25]=[CH:24]1

Participants

3

Reactant 2

HCID 66827Phenylboronic AcidHCID 22009837HCID 22009837, compound

Product 1

HCID 22009774HCID 22009774, compoundYield 92%

Procedure

In substantially the same manner as in Working Example 135, 2-(5-bromo-2-furyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole was allowed to react with phenylboronic acid to give 4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-(5-phenyl-2-furyl)oxazole. The yield was 92%. Recrystallization from ethyl acetate-isopropyl ether gave colorless needles, mp 130-131° C.

Sources & evidence

ORD record
ord-3ff084965a1940d5b7ad5c5e88fbbe0e
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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