Trifluoroacetic acid → HCID 178427568, compound

HRID 322552Notes

Reaction equation

HRID 322552 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:20]([OH:22])=[O:21])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:19])[NH:8][S:9]([C:12]1[CH:18]=[CH:17][C:15]([CH3:16])=[CH:14][CH:13]=1)(=[O:11])=[O:10].[S:30]1[CH:34]=[CH:33][N:32]=[CH:31]1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:1][C@H:2]([C:20]([OH:22])=[O:21])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:19])[NH:8][S:9]([C:12]1[CH:18]=[CH:17][C:15]([CH3:16])=[CH:14][CH:13]=1)(=[O:11])=[O:10].[S:30]1[CH:34]=[CH:33][N:32]=[CH:31]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178427600HCID 178427600, compound

Product 1

HCID 178427568HCID 178427568, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

To a solution of Boc—Arg(Tos)—Thiazole (300 mg, 0.6 mmol) in CH2Cl2 (10 mL) at 0° C. was added TFA (10 mL). The solution was stirred at 0° C. for 2 h. The solvent and excess TFA were evaporated to an oily residue which was used directly without further purification in Example 6.

Workup

  1. customThe solvent and excess TFA were evaporated to an oily residue which
  2. customwas used directly without further purification in Example 6

Sources & evidence

ORD record
ord-78ae128fb77d4415ae2108b1f3c91d02
Source dataset
uspto-grants-2001_04
Patent number
US06211154B1

Reaction notes

Loading…