反应详情

温度

0 °C

Diethyl oxalate (17.7 g) is added in one portion to a stirred suspension of potassium ethoxide (10.2 g) in anhydrous ether (1000 mL). The stirred mixture is cooled to 0° C., treated with 4-benzyloxyacetophenone (25 g) portionwise, and stirring continued for 3 hours. After standing at room temperature for 18 hours the reaction mixture is poured onto 1 N hydrochloric acid (500 mL) and the organic phase separated. The organic phase is washed with water, dried over magnesium sulphate and evaporated to give ethyl 4-benzyloxypheyl-2,4-dioxobutanoate (35 g).

1. waitAfter standing at room temperature for 18 hours
2. customthe organic phase separated
3. washThe organic phase is washed with water
4. dry with materialdried over magnesium sulphate
5. customevaporated