反应详情

A solution of 1-(3-iodophenyl)-2-(2-methylphenyl)ethanone (3.21 g) in dry tetrahydrofuran (30 mL) is treated with methyl acrylate (0.9 mL) and potassium tertiary butoxide (0.107 g). The reaction mixture is heated at reflux for 18 hours, evaporated and the residue partitioned between ethyl acetate (60 mL) and water (30 mL). The organic phase is dried over magnesium sulphate, evaporated and the residual solid washed with pentane to give methyl (RS)-5-(3-iodophenyl)-4-(2-methylphenyl)-5-oxopentanoate as a fawn coloured solid (3.39 g), m.p. 106-108° C.

1. temperatureThe reaction mixture is heated
2. temperatureat reflux for 18 hours
3. customevaporated
4. customthe residue partitioned between ethyl acetate (60 mL) and water (30 mL)
5. dry with materialThe organic phase is dried over magnesium sulphate
6. customevaporated
7. washthe residual solid washed with pentane