Water → HCID 11223563, compound

HRID 32313Notes

Reaction equation

HRID 32313 reaction equation
Cl.[Cl:2][C:3]1[CH:16]=[CH:15][C:6]([C:7](N2CCCCC2)=[O:8])=[CH:5][CH:4]=1.Cl[C:18]1[N:23]([CH3:24])[C:22](=[O:25])[CH:21]=[C:20]([C:26]2[CH:31]=[CH:30][N:29]=[CH:28][CH:27]=2)[N:19]=1.C([N:34]([CH2:37][CH3:38])[CH2:35][CH3:36])C.O.[CH3:40]N(C)C=O>>[Cl:2][C:3]1[CH:4]=[CH:5][C:6]([C:7]([CH:40]2[CH2:36][CH2:35][N:34]([C:18]3[N:23]([CH3:24])[C:22](=[O:25])[CH:21]=[C:20]([C:26]4[CH:31]=[CH:30][N:29]=[CH:28][CH:27]=4)[N:19]=3)[CH2:37][CH2:38]2)=[O:8])=[CH:15][CH:16]=1

Participants

6

Reactant 5

HCID 962WaterHCID 6228DimethylformamideHCID 8471TriethylamineHCID 112760814(3H)-Pyrimidinone, 2-chloro-3-methyl-6-(4-pyridinyl)-HCID 17954461(4-Chlorobenzoyl)piperidine hydrochloride

Product 1

HCID 11223563HCID 11223563, compoundYield 86%

Procedure

A solution of (4-Chlorobenzoyl)piperidine hydrochloride (55 mg, 0.226 mmol), 2-chloro-3-methyl-6-(4-pyridyl)-pyrimidine-4-one (50 mg, 0.226 mmol) and triethylamine (0.160 ml, 1.15 mmol) in N,N-dimethylformamide (1 ml) was stirred at 60° C. After stirring for several hours, water was added to the reaction mixture. The precipitate was filtered, washed with water and dried to give the title compound (76 mg, 86%).

Workup

  1. filtrationThe precipitate was filtered
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-18b0ca1c56a54974afa223547a9b7956
Source dataset
uspto-grants-2008_09
Patent number
US07427615B2

Reaction notes

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