Methanesulfonic Acid → 1-(3,4,5-Trimethoxybenzoyl)-3-(2-(4-(1-(2-ethoxyethyl)-1h-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-(3,4-dichlorophenyl)piperidine methanesulfonic acid salt

HRID 323257Notes

Reaction equation

HRID 323257 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:45]=[C:46]([O:50][CH3:51])[C:47]=1[O:48][CH3:49])[C:6]([N:8]1[CH2:13][CH2:12][CH2:11][C:10]([CH2:22][CH2:23][N:24]2[CH2:29][CH2:28][CH:27]([NH:30][C:31]3[N:35]([CH2:36][CH2:37][O:38][CH2:39][CH3:40])[C:34]4[CH:41]=[CH:42][CH:43]=[CH:44][C:33]=4[N:32]=3)[CH2:26][CH2:25]2)([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[C:16]([Cl:21])[CH:15]=2)[CH2:9]1)=[O:7].[CH3:52][S:53]([OH:56])(=[O:55])=[O:54]>C(OCC)(=O)C>[CH3:52][S:53]([OH:56])(=[O:55])=[O:54].[CH3:51][O:50][C:46]1[CH:45]=[C:5]([CH:4]=[C:3]([O:2][CH3:1])[C:47]=1[O:48][CH3:49])[C:6]([N:8]1[CH2:13][CH2:12][CH2:11][C:10]([CH2:22][CH2:23][N:24]2[CH2:29][CH2:28][CH:27]([NH:30][C:31]3[N:35]([CH2:36][CH2:37][O:38][CH2:39][CH3:40])[C:34]4[CH:41]=[CH:42][CH:43]=[CH:44][C:33]=4[N:32]=3)[CH2:26][CH2:25]2)([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[C:16]([Cl:21])[CH:15]=2)[CH2:9]1)=[O:7]

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 98752681-(3,4,5-trimethoxybenzoyl)-3-(2-(4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-(3,4-dichlorophenyl)piperidine

Product 1

HCID 880724741-(3,4,5-Trimethoxybenzoyl)-3-(2-(4-(1-(2-ethoxyethyl)-1h-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-(3,4-dichlorophenyl)piperidine methanesulfonic acid salt

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Combine 1-(3,4,5-trimethoxybenzoyl)-3-(2-(4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-(3,4-dichlorophenyl)piperidine (0.56 g) and methanesulfonic acid (0.16 g) in ethyl acetate (10 mL). Heat to reflux. After 1 hour concentrate in vacuo to give the title compound.

Workup

  1. temperatureHeat to reflux
  2. concentrationAfter 1 hour concentrate in vacuo

Sources & evidence

ORD record
ord-4fc1fdfd6c9a4dd08f5b44b4631dc7ec
Source dataset
uspto-grants-2001_04
Patent number
US06211199B1

Reaction notes

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