HRID323297

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6395

Methanesulfonic acid

CH4O3S

结构：CCOCCn1c(NC2CCN(CCC3(c4ccc(F)c(F)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21

HCID9831472

未命名化合物

PRODUCTS

生成物

结构：CCOCCn1c(NC2CCN(CCC3(c4ccc(F)c(F)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21.CS(=O)(=O)O

HCID88072770

未命名化合物

PROCEDURE

实验过程

Prepare by the method of Example 21.2 using 1-(3,4,5-trimethoxybenzoyl)-3-(2-(4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-(3,4-difluorophenyl)pyrrolidine (0.8 g) and methanesulfonic acid (0.24 g, 2.43 mmol) to give the title compound: mp; 225-228° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-961d3880964840b690ff96beb0fa886c
来源数据集: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06211199B1
来源说明: uspto-grants-2001_04

反应 SMILES

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:44]=[C:45]([O:49][CH3:50])[C:46]=1[O:47][CH3:48])[C:6]([N:8]1[CH2:12][CH2:11][C:10]([CH2:21][CH2:22][N:23]2[CH2:28][CH2:27][CH:26]([NH:29][C:30]3[N:34]([CH2:35][CH2:36][O:37][CH2:38][CH3:39])[C:33]4[CH:40]=[CH:41][CH:42]=[CH:43][C:32]=4[N:31]=3)[CH2:25][CH2:24]2)([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[C:15]([F:20])[CH:14]=2)[CH2:9]1)=[O:7].[CH3:51][S:52]([OH:55])(=[O:54])=[O:53]>>[CH3:51][S:52]([OH:55])(=[O:54])=[O:53].[CH3:50][O:49][C:45]1[CH:44]=[C:5]([CH:4]=[C:3]([O:2][CH3:1])[C:46]=1[O:47][CH3:48])[C:6]([N:8]1[CH2:12][CH2:11][C:10]([CH2:21][CH2:22][N:23]2[CH2:28][CH2:27][CH:26]([NH:29][C:30]3[N:34]([CH2:35][CH2:36][O:37][CH2:38][CH3:39])[C:33]4[CH:40]=[CH:41][CH:42]=[CH:43][C:32]=4[N:31]=3)[CH2:25][CH2:24]2)([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[C:15]([F:20])[CH:14]=2)[CH2:9]1)=[O:7]