反应详情

Combine methyl 3-methoxy-4,5-methylenedioxybenzoate (0.84 g, 4.0 mmol) and tetrahydrofuran (25 mL). Add a 1 M aqueous solution of lithium hydroxide (8.0 mL, 8.0 mmol). Heat to reflux. After 4 hours, cool the reaction, concentrate in vacuo to remove most of the tetrahydrofuran. Extract with ethyl acetate. Cool in a ice bath and acidify the aqueous layer with a 6 M aqueous hydrochloric acid solution to give a solid. collect the solid by filtration and dry to give the title compound.

1. temperatureHeat to reflux
2. temperaturecool
3. customthe reaction
4. concentrationconcentrate in vacuo
5. customto remove most of the tetrahydrofuran
6. extractionExtract with ethyl acetate
7. temperatureCool in a ice bath
8. customto give a solid
9. customcollect the solid
10. filtrationby filtration
11. customdry