反应详情

Combine methyl 3-methoxy-4,5-ethylenedioxybenzoate (0.46 g, 2.0 mmol) and tetrahydrofuran (15 mL). Add a 1 M aqueous solution of lithium hydroxide (2.5 mL, 2.5 mmol). Heat to reflux. After 15 hours, cool the reaction, concentrate in vacuo to remove most of the tetrahydrofuran. Cool in a ice bath and acidify with a 1 M aqueous hydrochloric acid solution to give a solid. Collect the solid by filtration and dry to give the title compound.

1. temperatureHeat to reflux
2. temperaturecool
3. customthe reaction
4. concentrationconcentrate in vacuo
5. customto remove most of the tetrahydrofuran
6. temperatureCool in a ice bath
7. customto give a solid
8. customCollect the solid
9. filtrationby filtration
10. customdry