反应详情

5-Acetyl-1-isopropylimidazole (Method 3; 15.3 g, 100 mmol) was dissolved in a mixture of DMF (90 ml) and DMF.DMA (150 ml) and the mixture was heated under reflux, under an atmosphere of nitrogen, for 18 hours. The reaction mixture was allowed to cool to ambient temperature and the product crystallised. The solid product was collected by filtration, washed with DMF.DMA and then ether and dried under vacuum at 40° C. to give the title compound (11 g, 53%) as a pale solid. NMR: 1.43 (d, 6H), 2.95 (m, 6H), 5.32 (m, 1H), 5.58 (d, 1H), 7.60 (m, 2H), 7.90 (s, 1H).

1. temperatureunder reflux, under an atmosphere of nitrogen, for 18 hours
2. customthe product crystallised
3. filtrationThe solid product was collected by filtration
4. washwashed with DMF
5. dry with materialDMA and then ether and dried under vacuum at 40° C.