反应详情

Combine (1-(ethoxycarbonylmethyl)-1H-benzimidazol-2-yl)(1-(t-butoxycarbonyl)piperidin-4-yl)amine (0.405 g, 1.00 mmol), aqueous hydriodic acid (0.29 mL, 57%), and methanol (15 mL). Heat to reflux. After 2 hour, cool to ambient temperature and add diethyl ether (100 mL) and stir to give a solid. After 1 hour, collect the solid by filtration, dissolve in methanol and add diethyl ether (100 mL) to give a solid. Collect the solid by filtration and dry in vacuo to give the title compound.

1. temperatureHeat to reflux
2. customto give a solid
3. waitAfter 1 hour
4. customcollect the solid
5. filtrationby filtration
6. dissolutiondissolve in methanol
7. additionadd diethyl ether (100 mL)
8. customto give a solid
9. customCollect the solid
10. filtrationby filtration
11. customdry in vacuo