Hydrochloric Acid → (1-(2-(trifluoromethoxy)ethyl)-1H-benzimidazol-2-yl)(piperidin-4-yl)amine hydrochloric acid salt

HRID 323513Notes

Reaction equation

HRID 323513 reaction equation
[F:1][C:2]([F:30])([F:29])[O:3][CH2:4][CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[NH:15][CH:16]1[CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18][CH2:17]1.[ClH:31]>O1CCOCC1>[ClH:31].[F:30][C:2]([F:1])([F:29])[O:3][CH2:4][CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[NH:15][CH:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22009444(1-(2-(trifluoromethoxy)ethyl)-1H-benzimidazol-2-yl)(1-(t-butoxycarbonyl)piperidin-4-yl)amine

Product 1

HCID 22009401(1-(2-(trifluoromethoxy)ethyl)-1H-benzimidazol-2-yl)(piperidin-4-yl)amine hydrochloric acid salt

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Combine (1-(2-(trifluoromethoxy)ethyl)-1H-benzimidazol-2-yl)(1-(t-butoxycarbonyl)piperidin-4-yl)amine and a solution of hydrochloric acid in dioxane (10 mL, 4 M). After 1 hour, evaporate in vacuo to give the title compound.

Workup

  1. customevaporate in vacuo

Sources & evidence

ORD record
ord-591b74fb9754415b930082a5b6576b57
Source dataset
uspto-grants-2001_04
Patent number
US06211199B1

Reaction notes

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