Triethylamine → HCID 20578846, compound

HRID 323548Notes

Reaction equation

HRID 323548 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[S:11]([NH:14][C@H:15]([C:20]([NH:22][C@H:23]([CH2:31][OH:32])[CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[O:21])[C:16]([CH3:19])([CH3:18])[CH3:17])(=[O:13])=[O:12].C(N(CC)CC)C.C(OCC)(=O)C>CS(C)=O.ClCCl>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[S:11]([NH:14][C@H:15]([C:20]([NH:22][C@H:23]([CH:31]=[O:32])[CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[O:21])[C:16]([CH3:19])([CH3:18])[CH3:17])(=[O:13])=[O:12]

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 20578847HCID 20578847, compound

Product 1

HCID 20578846HCID 20578846, compoundYield 69.1%

Reagents, catalysts & solvents 2

HCID 679Dimethyl SulfoxideSolvent2×HCID 6344DichloromethaneSolvent

Procedure

N-(2-Naphthalenesulfonyl)-L-tert-leucyl-L-phenylalaninol (1.6 g) was dissolved in dimethyl sulfoxide (20 ml) and dichloromethane (10 ml), and triethylamine (2.1 g) was added. The solution was stirred at room temperature while adding a solution (15 ml) of sulfur trioxide-pyridine complex (2.2 g) in dimethyl sulfoxide, which was followed by stirring for 2 hr. After the completion of the reaction, ethyl acetate was added. The mixture was washed with dilute hydrochloric acid, saturated aqueous solution of sodium hydrogencarbonate and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was washed with a mixed solution of hexane-ethyl acetate to give 1.1 g of N-(2-naphthalene-sulfonyl)-L-tert-leucyl-L-phenylalaninal (Compound 42) as white crystals. [Step 1]

Workup

  1. stirringby stirring for 2 hr
  2. additionwas added
  3. washThe mixture was washed with dilute hydrochloric acid, saturated aqueous solution of sodium hydrogencarbonate and saturated brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customThe solvent was evaporated under reduced pressure
  6. washthe residue was washed with a mixed solution of hexane-ethyl acetate

Sources & evidence

ORD record
ord-91e2a80ded9a43d7906de845888b7e24
Source dataset
uspto-grants-2001_04
Patent number
US06214800B1

Reaction notes

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