Ethyl bromoacetate → HCID 70228484, compound

HRID 323559Notes

Reaction equation

HRID 323559 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][N:3]=1.[Br:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12]>>[BrH:9].[NH:1]=[C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][N:3]1[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12]

Participants

3

Reactant 2

HCID 7748Ethyl bromoacetateHCID 661742-Amino-5-chloropyridine

Product 1

HCID 70228484HCID 70228484, compound

Procedure

To 2-amino-5-chloropyridine, compound 9 (Aldrich, 10 g, 0.078 mol) was added ethyl bromoacetate (30 mL, 0.269 mol) and the reaction mixture stirred at room temperature for 8 hours. The heavy white precipitate was removed by filtration and recrystallized from EtOH to yield 21.9 g (95%) yield of compound 11 as white crystals.

Workup

  1. customThe heavy white precipitate was removed by filtration
  2. customrecrystallized from EtOH

Sources & evidence

ORD record
ord-9d421ae32d564502bf9ceb0b1d823055
Source dataset
uspto-grants-2001_04
Patent number
US06214801B1

Reaction notes

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