Water → 4-Chloropyridine-2,6-dicarbaldehyde

HRID 323576Notes

Reaction equation

C(Cl)(=O)C(Cl)=O.[Cl:7][C:8]1[CH:13]=[C:12]([CH2:14][OH:15])[N:11]=[C:10]([CH2:16][OH:17])[CH:9]=1.C(N(CC)CC)C.O>C(Cl)Cl.CS(C)=O>[Cl:7][C:8]1[CH:13]=[C:12]([CH:14]=[O:15])[N:11]=[C:10]([CH:16]=[O:17])[CH:9]=1

Participants

Conditions

Temperature: -60 °C

Procedure

Oxalyl chloride (126.93 g, 154 mmol) and CH2Cl2 (80 mL) were placed in a 1 L, 3-neck round bottomed flask. The solution was cooled to −60° C. To the cooled solution, DMSO (24 mL) in CH2Cl2 (80 mL) was added over a 5 minutes period via dropping funnel. After 10 minutes, 4-chloro-2,6-dihydroxymethyl pyridine (12.13 g, 69.9 mmol) in DMSO (40 mL) was added over 5 minutes, also via dropping funnel. After 20 min., triethylamine (200 mL) was added and the reaction was stirred at −60° C. for an additional 5 minutes. The reaction mixture was then allowed to reach room temperature. Water (400 mL) was added to the flask. The aqueous mixture was extracted with several portions of CH2Cl2 and the organic fractions were added together, dried over Na2SO4, filtered and concentrated. The crude product was eluted through a silica gel (Aldrich 200-400 mesh, 60 Å) column with CH2Cl2 to give 8.20 g (69% yield) of pure 4-chloropyridine-2,6-dicarboxaldehyde as a bright yellow solid. 1H NMR (300 MHz, CDCl3) δ 10.12 (s), 8.11 (s). 13C NMR (CD3OD, 100 MHz) δ 191.26, 154.24, 147.55, 125.53•mp=163° C.

Workup

waitAfter 20 min.
customto reach room temperature
extractionThe aqueous mixture was extracted with several portions of CH2Cl2
additionthe organic fractions were added together
dry with materialdried over Na2SO4
filtrationfiltered
concentrationconcentrated
washThe crude product was eluted through a silica gel (Aldrich 200-400 mesh, 60 Å) column with CH2Cl2

Sources & evidence

ORD record: ord-07e2338604e14298ba23c2f29495d0a2
Source dataset: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06214817B1

Reaction notes

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