反应详情

温度

0 °C

To a mixture of 6.3 g of 4-benzyloxy-3-ethyl-5-methylphenol, 3.2 g of triethylamine and 50 ml of chloroform was added dropwise 4.0 g of benzoyl chloride, while stirring at 0° C. After stirring at room temperature for 6 hours, the reaction mixture was concentrated under reduced pressure to give a residue. To the residue was added 100 ml of 10% hydrochloric acid, and the mixture was extracted with 100 ml of ethyl acetate. The ethyl acetate layer was successively washed 10% hydrochloric acid, saturated aqueous sodium hydrogen carbonate solution and saturated saline solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure, which afforded 8.4 g of crude 4-benzyloxy-3-ethyl-5-methylphenyl benzoate (93% yield).

1. stirringAfter stirring at room temperature for 6 hours
2. concentrationthe reaction mixture was concentrated under reduced pressure
3. customto give a residue
4. extractionthe mixture was extracted with 100 ml of ethyl acetate
5. dry with materialdried over anhydrous magnesium sulfate
6. concentrationconcentrated under reduced pressure, which